Researchers at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) have identified a potential drug combination to treat uveal melanoma, a type of eye cancer. Lead author Amanda Truong, trainee in the McMahon Lab at HCI and student at the U of U, explains uveal melanoma patients frequently have changes in genes called GNAQ and GNA11, which are key targets for these drugs. This study was published in the journal Clinical Cancer Research. “Uveal melanoma is a relatively
The DG of the World Health Organisation (WHO), Dr Tedros Adhanom Ghebreyesus, has described health as the essential underpinning of productive, resilient and stable economies. He described the COVID-19 pandemic as a powerful demonstration that health is not a by-product of growth. The DG said this while delivering opening remarks at the G20 Leaders Summit. He threw his weight behind the call earlier this week for an immediate investment of US$4.5 billion for vaccines. “This is the smart thing to do, both
The Joint United Nations Programme on HIV/AIDS (UNAIDS) has announced that it is strongly encouraged by new study results showing that the antiretroviral medicine cabotegravir, which is administered by injection every two months, prevents HIV among women. The study shows that the long-acting injections among women in sub-Saharan Africa were 89% more efficient in preventing HIV compared to daily tablets of pre-exposure prophylaxis (PrEP). “These results are hugely significant. UNAIDS has long been calling for additional, acceptable and effective HIV prevention options
A genetically edited form of a herpes simplex virus — rewired to keep it from taking refuge in the nervous system and eluding an immune response — has outperformed a leading vaccine candidate in a new study from the University of Cincinnati, Northwestern University and the University of Nebraska-Lincoln. Published Nov. 6 in the journal Nature Vaccines, the study found that vaccinating guinea pigs with the modified live virus significantly increased the production of virus-combating antibodies. When challenged with a virulent strain
The President of Nigeria, Muhammadu Buhari, has announced that Nigeria will be joining the urgent global call for a People’s Vaccine for COVID-19. The President endorsed the initiative and released an official public statement in favour of the campaign. “Learning from the painful lessons from a history of unequal access in dealing with diseases such as HIV we must heed the warning that “those who do not remember the past are doomed to repeat it”,” said Mr Buhari.
A group of drugs used to treat HIV and hepatitis B could be repurposed to prevent type 2 diabetes, a new study suggests. Researchers found that patients taking the drugs had a 33% lower risk of developing diabetes. The scientists say that the risk reduction makes sense based on how the drugs are known to work, and noted that one of the drugs, lamivudine, improved insulin sensitivity significantly in human cell samples and in a mouse model of diabetes. (In type